Cytokine-secreting follicular T cells shape the antibody repertoire

The Effect of Beta Interferon on Dendritic Cells and Cytokine Synthesis by CD4+ T Cells

Background: Dendritic cells (DC) are a key regulator of the immune response, and interferon- beta (IFN-β) is considered an immunomodulatory molecule for DC. Objective: The purpose of this study was to evaluate the ability of IFN-β treated DC to induce cytokine secretion by CD4+ T cells. Methods: Dendritic cells were generated from blood monocytes with granulocyte-monocyte colony-stimulating fac...

T follicular helper cells, T follicular regulatory cells and autoimmunity.

CD4(+)T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity. Tfh cell differentiation depends on various factors including cell-surface molecule interactions, extracellular cytokines and multip...

Human Vγ9Vδ2-T Cells Synergize CD4+ T Follicular Helper Cells to Produce Influenza Virus-Specific Antibody

1 Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Pokfulam, Hong Kong, 2 State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China, 3 State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guan...

Intestinal Extravasation of IgA Antibody-Secreting Cells

Microfluidic Trapping of Antibody-secreting Cells

The development of antibody-based drugs typically begins with the isolation and screening of thousands of antibody-secreting cells, often requiring 4-6 weeks to identify only 1-10 cell lines of interest. We are developing a novel immunobiosensing device to afford direct and rapid assessment of the antibody production of each of thousands of living cells captured on a single slide. Each cell sha...